The 17-game NFL regular season schedule creates steep structural barriers to an undefeated campaign, with cumulative injury risk, weekly matchup variance, and league-wide parity routinely derailing even the most talented rosters. No team has finished without a loss since the 2007 Patriots, and the added game since 2021 has further compressed margins for error across divisional and conference play. Recent seasons show top contenders—regardless of roster strength or coaching stability—typically absorb at least two to four defeats from factors such as key injuries, short turnarounds, and opponent rest advantages. Trader consensus at 74% for “No” aligns with these historical patterns and the absence of any preseason indicators suggesting a roster capable of navigating the full slate unscathed.