US-Mexico law enforcement coordination, including DEA intelligence sharing and Treasury sanctions, continues to target Sinaloa Cartel factions amid their internal conflict between Los Mayos and Los Chapitos. Recent actions include September 2026 OFAC designations against Ismael Zambada Sicairos (“Mayito Flaco”) and associated networks, alongside arrests of regional operators and financial facilitators in Sinaloa and other states. CJNG faces added pressure following the 2026 death of Nemesio Oseguera Cervantes (“El Mencho”) and subsequent captures of potential successors, with US rewards programs and extradition processes remaining active for high-profile figures. Ongoing cartel fragmentation, plaza-level disruptions, and cross-border operations through year-end create the main variables for remaining 2026 outcomes.