Josh Allen's dual-threat production, including elite rushing volume and multiple multi-TD games, has positioned him as the early fantasy points leader through six weeks, while Brock Purdy's efficient passing attack with the 49ers and Drake Maye's emerging deep-ball accuracy in New England have kept them in the top tier of scoring. Lamar Jackson's ongoing ankle absence and Jalen Hurts' calf injury have sidelined two perennial top-12 candidates, opening opportunities for others like Jordan Love, Dak Prescott, and Matthew Stafford amid favorable upcoming schedules. Quarterbacks facing favorable pass defenses or with strong supporting casts, such as Caleb Williams trending toward a return, could climb with sustained volume, though bye weeks, potential weather impacts in late season, and injury risks continue to introduce volatility for the final top-12 cutoff.