**Republican Harriet Hageman and Democrat James W. Byrd are the nominees in Wyoming’s open Senate race on November 3, 2026.** All major forecasters rate the contest Solid or Safe Republican, consistent with the state’s recent voting patterns and the absence of general-election polling. Hageman’s comfortable August primary win and stronger fundraising contrast with Byrd’s lower profile and limited resources, yet the precise margin remains fluid because no recent surveys exist and open-seat dynamics can shift turnout. Traders see the widest probability mass in the 25–45 point Republican range, reflecting uncertainty over whether Hageman will match or exceed historical GOP margins or face modest compression from Democratic base mobilization. Late-cycle advertising, national political environment, or unusually high or low turnout in rural counties could widen or narrow the final spread.