No at 79.5% reflects the absence of any pathogen currently exhibiting sustained human-to-human transmission with pandemic-scale potential, according to CDC and WHO surveillance. Recent localized events, including the contained Andes hantavirus cluster on a cruise ship and the Bundibugyo Ebola outbreak in limited DRC provinces, have not generated widespread secondary cases. Measles resurgences stem from vaccination gaps rather than novel strains, while other reports center on foodborne or vector issues like cyclosporiasis and West Nile virus. Post-COVID improvements in genomic sequencing and early-warning systems further support trader consensus that the roughly 18-month window to 2028 carries low probability absent an unexpected zoonotic spillover with high transmissibility.