Mexican authorities have intensified operations against the Jalisco New Generation Cartel (CJNG) in 2026, including the February killing of founder Nemesio “El Mencho” Oseguera Cervantes and a series of subsequent arrests of regional commanders such as “El Jardinero,” “R1,” “El Señor de la T,” “El Tanque,” and most recently Rafael “R2” Álvarez Ayala on November 8. The R2 operation in Jalisco, supported by DEA intelligence and resulting in 19 additional detentions, highlights sustained U.S.-Mexico cooperation on drug trafficking, extortion, and homicide charges, with multiple suspects facing extradition. Parallel actions against Sinaloa Cartel figures, including 14 arrests in Chiapas on November 11, reflect ongoing fragmentation within major organizations. These enforcement patterns and bilateral coordination shape trader assessments of which remaining leaders face custody before year-end.