Mercedes drivers Kimi Antonelli and George Russell enter the Mexico City Grand Prix as frontrunners for podium positions, reflecting their season-long dominance with over 500 combined points. Antonelli leads the drivers' championship by a wide margin, while Lewis Hamilton at Ferrari and Lando Norris at McLaren remain consistent threats based on recent results. High altitude at the Autódromo Hermanos Rodríguez reduces engine power and cooling efficiency, historically favoring teams with strong power units and setup adaptability. Red Bull's Max Verstappen has shown variable pace this year amid ongoing development challenges. Preceding events including the United States Grand Prix will shape recent form and tire management strategies heading into the November 1 race.