Incumbent Republican Joe Wilson, who secured his party's nomination in the June 2026 primary, faces Democrat Zyon Khalifa in South Carolina's 2nd district on November 3. The R+7 Partisan Voter Index and Wilson's long tenure anchor trader expectations for a Republican victory, yet the split pricing across narrow margin bands reflects uncertainty over the final spread. National generic ballot trends, midterm turnout patterns among suburban and military voters, and any late shifts in fundraising or endorsements could compress or expand the margin. Historical precedent shows this seat rarely flips, but comparable districts have seen single-digit outcomes during wave cycles.